The Life Scientific

As recently as a few years ago, the idea of a self-administered injection that would deliver proven weight-loss results might have sounded fantastical. Today, these medications are a reality and a global phenomenon; hailed in many quarters as “miracle drugs" for their success in treating obesity and diabetes.
They do this by replicating a gut hormone called GLP‑1, which tells the brain you’ve eaten enough and nudges the pancreas to release insulin; and this hormone was discovered and decoded thanks to years of work by today's guest.
Jens Juul Holst is a Professor of Medical Physiology and Biomedical Sciences at the University of Copenhagen. His efforts laid the groundwork for today’s weight loss jabs, earning him a slew of high-profile accolades and awards. Now it seems they might not only have positive impacts on obesity and diabetes, but also other health issues...
But alongside the big success comes some big questions: including concerns over side effects, weight regain post-treatment, the black market in such drugs, and their cost and accessibility.
In a frank conversation with Professor Jim Al-Khalili, Jens address these issues and shares his hopes for the future of GLP-1-focused research.
Presented by Jim Al-Khalili
Produced by Lucy Taylor
A BBC Studios production

It's a rare thing to encounter a medical specialist who has experience of his field from the expert and the patient perspective - but not unheard of...
Jim Ashworth-Beaumont is an orthotist and prosthetist who spent years helping people adapt to life with artificial limbs and musculoskeletal supports, before a near-fatal accident left him relying on both.
This twist of fate might have derailed many - but Jim drew on reserves of resilience and determination forged long before his accident; initially in the army, then by returning to education to earn the qualifications he missed out on as a youngster. He put himself through night school before earning a place to study Prosthetics and Orthotics at the University of Strathclyde. Later, while working at London’s Royal National Orthopaedic Hospital, Jim completed a Master’s in Neurorehabilitation, and a PhD in Health Studies – driven by a fascination with how the human body adapts under pressure.
But in 2020, while training for a triathlon, Jim was involved in a catastrophic cycling accident that nearly killed him - and cost him an arm.
He tells Jim Al-Khalili how the incident gave him a whole new insight into his patients’ experience and made him more determined than ever to achieve his goals.
Presented by Jim Al-Khalili
Produced by Lucy Taylor
A BBC Studios production for Radio 4

Ever heard of the unsuccessful Dutch painter who decided to humiliate his critics by forging Vermeers, which the artworld subsequently dubbed 'masterpieces'?
Or the businessman who bought a Marc Chagall painting that he displayed with pride for years, before a television investigation revealed to his horror that it was a fake?
Today we're exploring the scientific techniques used to reveal forged artworks - and bring down scammers still trying to make millions from fake masterpieces.
Jehane Ragai is an Emeritus Professor of Chemistry at the American University in Cairo, with a passion for science matched by her love of arts and culture. Early in her career Jehane helped analyse the Great Sphinx of Giza and later became fascinated by the world of art forgery, leading to her acclaimed book, ‘The Scientist and the Forger’.
Her life has not been without its difficulties, but - perhaps unsurprisingly, as the daughter of renowned Egyptian feminist Doria Shafik - she’s not one to shy away from a challenge. And as she tells Professor Jim Al-Khalili, Jehane feels priveleged to have been able to integrate her twin passions into a career; advice she now passes on to her students.
Presented by Jim Al-Khalili
Produced by Lucy Taylor
A BBC Studios production for Radio 4

Tony Juniper is an environmentalist who has worn many hats, over the course of his career.
After developing a passion for birds in childhood, his first job saw him working to save endangered parrots - including a successful effort to bring back the Spix's macaw from the edge of extinction. Tony went on to hold leading campaigning roles with some of the world's best known environmental organisations, from Friends of The Earth to the World Wildlife Fund. He also acted as an advisor to King Charles's International Sustainability Unit and co-authored three books with the monarch.
Today, Tony has swapped lobbying and campaigning for advising the government, as head of the advisory body Natural England: not without its challenges, but he says they are still outweighed by the positives.
Talking to Professor Jim Al-Khalili about his enduring love for nature and hopes for the future, Tony explains his optimism that we can and will recognise the urgent need to protect and restore our planet; and why ultimately, that means saving ourselves.
Presented by Jim Al-Khalili
Produced by Lucy Taylor for BBC Studios

The COP30 climate summit is taking place in the Brazilian city of Belém, a gateway to the Amazon rainforest, which continues to face widespread deforestation. We all know that our climate is changing and that we are largely responsible for this, but we can’t tackle the problem unless we understand what’s going on.
One scientist who’s done more than most to rectify this is Professor Pierre Friedlingstein. He’s a prominent climate scientist and Chair in Mathematical Modelling of the Climate System at Exeter University. His models have transformed our understanding of climate change, revealing a complex dynamical system with carbon at its centre, cycling between the atmosphere, oceans and land, to directly influence the level of carbon dioxide in the atmosphere.
Pierre is actively involved in assessing the state of our climate through the Intergovernmental Panel on Climate Change and, as director of the Global Carbon Budget, estimates the remaining amount of carbon dioxide that can be emitted before we breach our global climate targets. It’s the ultimate test of effective climate action and the latest annual update will be released at COP.
Pierre explains how we can all play our part to reduce carbon emissions, and he practises what he preaches - he won’t be flying to COP this year so as to minimise his own carbon footprint.
Presented by Jim Al-Khalili
Produced by Beth Eastwood
Executive Producer: Alexandra Feachem
A BBC Studios Production