Ep. 294: “HSC Development and Regulation” Featuring Dr. Margaret Goodell
Dr. Margaret "Peggy" Goodell is the Vivian L. Smith Chair in Regenerative Medicine and Director of the Stem Cell and Regenerative Medicine Center at Baylor College of Medicine. Her research focuses on HSC regulation and aging. She talks about her discovery of a side population of HSCs, as well as her work on DNMT3A mutation and clonal hematopoiesis of indeterminate potential. Finally, she discusses the rich research environment in Houston.
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1:26:47
Ep. 293: “Cell Atlases” Featuring Dr. Sarah Teichmann
Drs. Sarah Teichmann is a Member of the Department of Medicine and Professor of Stem Cell Medicine at the Cambridge Stem Cell Institute. She talks about the plasticity of different cell types and developing whole-organ cell atlases for organs such as the thymus. She also discusses Human Cell Atlas project and overcoming skepticism in its early days. Finally, she talks about integrating computational and wet lab biology, and running an interdisciplinary research group.
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1:31:44
Ep. 292: “Biomedical Ethics” Featuring Prof. Hank Greely
Professor Hank Greely is the Deane F. and Kate Edelman Johnson Professor of Law and Professor, by courtesy, of Genetics at Stanford University. He is also the Director of the Stanford Center for Law and the Biosciences. He talks about his career path into bioethics and ethical considerations for organoids, bodyoids, and embryo models. He also discusses the potential future of reproduction, including gametogenesis, ectogenesis, and genetic selection and editing of embryos.
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1:28:15
Ep. 291: “Functional Precision Medicine” Featuring Dr. Scott Younger
Dr. Scott Younger is the Director of Disease Gene Engineering within the Genomic Medicine Center at Children's Mercy Hospital. His research focuses on producing patient-derived cellular models to develop functional precision medicine. He talks about using personalized antisense oligonucleotides to reverse disease phenotypes in organoid models of Duchenne muscular dystrophy. He also discusses his lab's personal connections to the rare disease community and the opportunities for collaborations with clinicians at Children's Mercy.
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1:25:08
Ep. 290: “ISSCR 2025: Illuminating the Future” Featuring Drs. Valentina Greco, Kathryn Cheah, and Eugenia Piddini
Dr. Valentina Greco is the President of the International Society for Stem Cell Research (ISSCR), and Professor of Genetics and Co-Chair of the Status of Women in Medicine at Yale University. Dr. Kathryn Cheah is an ISSCR Program Committee Co-Chair and Emeritus Professor and Chair of Biochemistry at Hong Kong University. Dr. Eugenia Piddini is also an ISSCR Program Committee Co-Chair and Professorial Research Fellow in Cell Biology and School Research Director at the University of Bristol.
They talk about the upcoming ISSCR 2025 meeting in Hong Kong from June 11-14, 2025. They discuss the meeting's global focus, program highlights, opportunities for early-career researchers, and what they're looking forward to in Hong Kong.
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