EHA Unplugged

In this episode, Prof André Baruchel discusses the role of CAR T-cell therapy in children with B-cell acute lymphoblastic leukemia (B-ALL). He reviews current indications for CAR T-cell treatment, including relapsed and refractory disease, and explores whether CAR T could move earlier in the treatment pathway. The discussion also examines how CAR T-cell therapy compares with transplantation, blinatumomab, and other salvage strategies, as well as the factors that influence long-term outcomes and relapse risk.  

The conversation highlights key questions surrounding the role of allo-HSCT in the CAR T era. Prof Baruchel also explores emerging approaches designed to improve outcomes, including dual-targeted CARs, strategies to enhance cellular persistence.

Listen now for insights into how fourth-generation CAR constructs that modify the tumour microenvironment, and in vivo CAR therapies may further transform the treatment of pediatric B-ALL.

Guests:  Prof André Baruchel 
Affiliation: Professor of Pediatrics, Université Paris-Cité; former Head of the Pediatric Hematology Immunology Department, Hôpital Robert-Debré, Paris

Host: Leah DeLeon 

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In this episode of EHA Unplugged, Prof Marion Subklewe discusses one major challenge facing CAR T-cell therapy in Europe: ensuring that eligible patients are referred for treatment. She explains how access has improved since the first CAR T-cell approvals, but highlights that many eligible patients still do not receive these potentially curative therapies. The discussion explores differences between European healthcare systems, barriers to referral, and persistent misconceptions about patient eligibility.  

Prof Subklewe advocates for structured referral pathways and multidisciplinary boards that assess all eligible patients in collaboration with CAR T-cell experts. She argues that treatment eligibility should not depend solely on individual physicians and highlights the benefits of coordinated networks, shared decision-making, professional education, and patient engagement.  

Listen now for insights into how stronger referral systems could help more patients access CAR T-cell therapy across Europe.

This podcast episode is supported by Bristol Myers Squibb. 

Guests: Prof Marion Subklewe
Affiliation: 
LMU – University Hospital, LMU Munich   
Department of Hematology/Oncology   
LMU- Gene Center Munich   
Laboratory of Translational Cancer Immunology   
Germany 

Host: Isabel Olivera-Martínez, PhD, EHA Medical Writer

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In this episode, Dr Alexandra Martínez Roca and Dr Beatriz Merchán Muñoz discuss how their team at Hospital Clínic de Barcelona has developed a fully outpatient programme for CAR T-cell therapy. They explain the evolution of their at-home programme, from outpatient transplantation and supportive care to outpatient CAR T administration, and describe the key clinical and logistical requirements for patient selection. The discussion explores caregiver training, monitoring for cytokine release syndrome and neurotoxicity, and the importance of dedicated multidisciplinary teams.  

The guests also share their experience with outpatient CAR T across academic and commercial products, highlighting safety outcomes, early discharge strategies, resource utilisation, and patient-centred benefits. They discuss practical considerations for centres interested in establishing similar programmes, including infrastructure, staffing, legislation, and continuous evaluation. Listen now for insights into the opportunities and challenges of delivering CAR T therapy beyond the hospital ward.  

This podcast episode is supported by Bristol Myers Squibb. 

Guests: Dr Alexandra Martínez Roca and Dr Beatriz Merchán Muñoz 
Affiliation: Hospital Clínic de Barcelona, Spain  

Host: Isabel Olivera-Martínez, PhD, EHA Medical Writer

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Artificial intelligence is opening new possibilities in the design of next-generation immunotherapies. In this episode of EHA Unplugged, Dr Andrea Schmidts discusses how AI-driven approaches are reshaping the development of chimeric antigen receptor (CAR) T-cell therapies, particularly at the design stage of the CAR receptor binding domains.  

Dr Schmidts explains how structure-based AI models can generate entirely new protein binders, moving beyond the traditional reliance on monoclonal antibody–derived fragments. The conversation explores how these tools enable large-scale exploration of CAR designs, the experimental challenges of validating thousands of candidates, and the potential to tailor therapies that overcome resistance mechanisms such as antigen escape. Looking ahead, Dr. Schmidts highlights the role of AI across the entire CAR T-cell development pipeline—from early design to testing and manufacturing—and reflects on the practical and regulatory considerations of bringing AI-designed therapies to the clinic. 

Guest:  Dr Andrea Schmidts
Affiliation: Emmy Noether Group Leader, Medicine III – Hematology/Oncology, Technical University of Munich, Germany 
Host: Leah de Leon

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In this episode, Prof Benoit Tessoulin examines how real-world evidence from the French DESCAR-T registry is expanding our understanding of CAR T-cell therapy beyond clinical trials. He explains how the registry captures data from patients considered for CAR T-cell treatment, including those who do not ultimately receive therapy, and explores what these data reveal about patient selection, treatment outcomes, bridging therapy, and comparisons between different CAR T-cell products.  

The discussion also examines how real-world populations differ from clinical trial cohorts, in what measure registry data have confirmed the effectiveness of CAR T-cell therapy in routine practice, and what has been learned about toxicities such as CRS, ICANS, and infections. Prof Tessoulin highlights the importance of timely referral, evolving product selection strategies, and the growing role of patient registries in informing clinical decision-making and future research. Listen now for insights into how real-world data are informing CAR T-cell therapy updates. 
This podcast episode is supported by Bristol Myers Squibb. 
Guest:  Prof Benoit Tessoulin
Affiliation: Hematology Department, Centre Hospitalier Universitaire Nantes, France
Host: Isabel Olivera-Martínez, PhD, Medical Writer for EHA  

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