The Human Upgrade: Biohacking for Longevity & Performance

Raw Garlic "Ultimate Biohack" Trend Faces Scientific Scrutiny
Raw garlic has gone viral as a morning ritual, with fans crushing a clove, mixing it with honey, and crediting it with everything from lower cholesterol and better insulin sensitivity to cleared acne, eliminated brain fog, and colds cured within 24 hours. The biochemistry behind the trend is real: garlic contains no allicin until it's crushed or chopped, which mixes an enzyme with a sulfur compound to form the active compound, and letting it sit for ten to fifteen minutes before cooking preserves more of that activity. Host Dave Asprey separates what the human data actually supports, modest blood pressure and cholesterol effects, real antimicrobial properties, and a genuine bleeding-risk caution for anyone on blood thinners, from the unproven parasite-cleanse and brain fog claims driving the trend online, drawing on his own EEG tracking to challenge the cognitive benefit narrative directly.
Sources:
https://nypost.com/2026/09/01/health/is-garlic-the-ultimate-biohack/
https://holisticheartcenters.com/new-cholesterol-guidelines-2026/
~~

HEPA Air Filtration Linked To Measurable Brain Function Improvements In One Month
A new study found that older adults using true HEPA filtration to reduce indoor fine particulate matter saw small but measurable cognitive improvements after just one month, adding to a growing body of evidence connecting air pollution exposure to neuroinflammation and long-term cognitive decline. Host Dave Asprey breaks down why clean air belongs in the biohacking conversation alongside supplements and training protocols, and why the World Health Organization's decision to list air pollution as a modifiable dementia risk factor is a bigger deal than it sounds.
Sources:
https://www.sciencedaily.com/releases/2026/08/260830000016.htm
https://health.yahoo.com/conditions/neurological/dementia/articles/7-dementia-risk-factors-revealed-110006268.html
~~

Egg Yolk-Derived Peptides Show Neuroprotective Effects Against Oxidative Stress
New research on phosphopeptides isolated from egg yolk phosvitin found that the compounds reduced reactive oxygen species, improved antioxidant defense markers, and increased neuron survival in cells exposed to oxidative stress in the lab. Host Dave Asprey connects this early but promising finding to his long-standing case for the whole egg, yolk included, as one of the most nutrient-dense foods available, and flags what would need to happen next for this to translate into a usable protocol.
Source:
https://www.news-medical.net/news/20260827/Egg-yolk-peptides-protect-brain-cells-from-oxidative-stress.aspx
~~

Heat Stroke Survivors Face Elevated Cardiovascular Risk Years Later, Research Shows
A closer look at heat stroke recovery reveals it's rarely a one-day event. Survivors of classic heat stroke had three and a half times the rate of ischemic heart disease twelve years later compared to matched controls, along with elevated long-term risk of kidney disease and lingering heat intolerance, fatigue, and dizziness. Host Dave Asprey draws the line between the controlled heat stress he uses deliberately in sauna and hyperthermic conditioning and the uncontrolled, uncooled heat exposure that leaves this kind of lasting cardiovascular damage, and what that distinction means for how to think about any stressor.
Source:
https://www.latimes.com/science/story/2026-09-01/even-people-who-appear-to-recover-from-heatstroke-may-face-health-issues-later
~~

Long-Term Melatonin Use Linked To Nearly Double Heart Failure Risk In Large Cohort Study
A cohort study of over 130,000 adults with chronic insomnia found that those who used melatonin for a year or more had nearly double the rate of heart failure and all-cause mortality compared to non-users, along with a three and a half times higher rate of heart failure hospitalization. Host Dave Asprey walks through why this is observational data, not proof of causation, and why he's stayed a low-dose, occasional melatonin user for years rather than a nightly one, plus what the real underlying driver of chronic insomnia might be for listeners still relying on it every night.
Source:
https://www.sciencedaily.com/releases/2026/08/260829035228.htm
~~

This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want the latest research on nutrition, air quality, brain health, heat stress, and sleep translated into what actually matters for your biology right now. Host Dave Asprey connects viral trends, clinical data, and decades of context into practical frameworks for taking control of your own health decisions.

New episodes every Tuesday, Thursday, Friday, and Sunday.

Keywords: raw garlic biohack, allicin formation, garlic blood pressure, aged garlic extract, garlic cholesterol, HEPA air purifier brain health, PM2.5 cognitive decline, air pollution dementia risk, egg yolk phosvitin peptides, oxidative stress neuroprotection, egg yolk nutrition, heat stroke cardiovascular risk, heat stroke recovery, hyperthermic conditioning, sauna protocol, melatonin heart failure risk, chronic insomnia, sleep hygiene, circadian rhythm, biohacking news 2026

Thank you to our sponsors!
Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com
Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.
iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Intro
00:19 – Garlic & Brain Fog
02:06 – HEPA Filtration & Cognition
03:20 – Egg Yolk Peptides
04:16 – Heat Stroke
05:22 – Melatonin
06:54 - Wrapup
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jenny McCarthy on Reversing Autism, Healing Mold Toxicity, and the Biohacking Protocol Big Pharma Doesn't Want You to Know

Back with another long one! Autism, mold poisoning, and cognitive decline share more root causes than most doctors admit, and this episode hands you the biohacking playbook to reverse all three.

Want to try Jenny's makeup and skincare line? Visit https://bit.ly/Formless-Beauty and use code DAVE to unlock a discount.

Host Dave Asprey sits down with Jenny McCarthy Wahlberg, a New York Times bestselling author, actress, comedian, and 14-season judge on The Masked Singer who became one of the most trusted voices in the autism community after her son's regression following a vaccine reaction. She documented his recovery in books including Louder Than Words and Healing and Preventing Autism, founded the vegan, cruelty-free beauty brand Formless Beauty, and now develops unscripted television, documentaries, and podcasts with her husband Donnie Wahlberg through their Work Baby Productions banner under a first look deal with Lionsgate.

Dave and Jenny trace her son's autism diagnosis back to a vaccine reaction and walk through the biohacking protocol that helped him recover, including candida detox, activated charcoal binders, collagen and hypermobility support, and hacking his gut with a low toxin diet that removed wheat and dairy. They connect autism to mitochondria energy collapse and neuroinflammation, and explain how nootropics like modafinil restore focus without the crash of stimulants.

The conversation moves into longevity and human performance strategies for adults, covering low dose Cialis for brain blood flow, DHEA and thyroid optimization for women over 35, peptide protocols including melanotan and Retatrutide, cyclical ketosis and fasting alternatives, and why hormone replacement therapy reverses aging instead of causing cancer.

They dig into functional medicine tools for everyday life: electrolytes and salt for blood pressure and sleep optimization, blackout darkness for circadian repair, baking soda for metabolism and alkaline balance, and why Jenny trusts krill oil over fish oil for anti-aging support. Dave breaks down ibogaine and neuroplasticity for brain repair, defends his carnivore leaning diet, shares why Danger Coffee still starts his morning, and calls out AI chatbots for pushing censored health narratives.

This is essential listening for anyone interested in biohacking, human performance, longevity, functional medicine, brain optimization, and building a smarter, not harder approach to supplements and long-term health.

You'll Learn:
How mold and candida trigger PANS and PANDAS, and why they mimic autism symptoms
Why activated charcoal timing determines whether it works as a binder
The link between collagen, hypermobility, and leaky gut in autism and long-term brain function
How modafinil, nicotine, and Cialis support brain optimization, focus, and mitochondria function
Why hormone replacement therapy and DHEA reverse aging in women after 35
The truth about ketosis supplements, structured water, and alkaline water myths
How darkness, light exposure, and electrolytes rebuild sleep optimization and metabolism

Thank you to our sponsors!
- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
- MOD | Visit https://mod.com/ for a consultation and get 10% off your first order plus free shipping with promo code DAVE.
- KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off
- Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighs or top sirloins in every box for a year with free shipping always.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Jenny McCarthy Wahlberg, autism recovery, vaccine injury, biohacking, longevity, mitochondria, neuroinflammation, candida detox, mold toxicity, activated charcoal, hypermobility, collagen, modafinil, nootropics, human performance, hormone replacement therapy, DHEA, peptides, melanotan, ketosis, fasting, functional medicine, Danger Coffee, Smarter Not Harder, Dave Asprey, anti-aging, sleep optimization, brain optimization, metabolism, carnivore, ibogaine, neuroplasticity, supplements, PANS PANDAS

Resources:
• Want To Try Jenny's Makeup And Skincare Sine? Visit https://bit.ly/Formless-Beauty and use code DAVE to unlock a discount.
• Check Out Formless Beauty On YouTube: https://www.youtube.com/@formlessbeauty
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

Timestamps:
00:00 – Trailer
01:20 – The Human Upgrade Starts
07:13 – Detoxing Candida: The Turnaround
15:00 – The Anti-Vaxxer Backlash
23:02 – The Many Flavors of Autism
29:36 – Powering Up the Autistic Brain
35:59 – The Bile & Binder Protocol
43:53 – Intuition, Trust & Integrity
53:40 – Building an Ethical Beauty Brand
58:34 – Sensory Sensitivities & Clean Living
01:04:00 – Modafinil: The Focus Drug
01:13:45 – Mold Illness, Memory & Brain Health
01:18:26 – Jenny McCarthy's Show Starts
01:22:45 – Dave's Mold Poisoning Story
01:31:04 – Nicotine, Ibogaine & Biohacking Extremes
01:38:33 – When Biohacking Goes Too Far
01:45:07 – Peptides, Hormones & Anti-Aging Hacks
01:52:24 – Hormone Replacement Therapy for Women
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The 3 "Longevity Drugs" That Fail the Data, and 4 Repurposed Ones Worth Considering

Back with another solo episode, this one on Big Pharma! Metformin, rapamycin, and statins are three of the most trusted names in longevity, and none of them hold up the way you've been told. This episode breaks down the human data behind the drugs everyone assumes are safe, and reveals four lesser-known repurposed pharmaceuticals that might do more for your metabolism, mitochondria, and lifespan.

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Dave walks through why metformin blunts the muscle-building signal your body needs from exercise, why rapamycin's stunning mouse studies fell apart in the 2025 PEARL trial, and why statins help one person in a hundred while draining the CoQ10 your mitochondria depend on. Then he lays out the yes list: tadalafil for vascular and brain health, SGLT2 inhibitors for metabolic and kidney protection, acarbose for gut and longevity markers, and low dose naltrexone for calming an overactive immune system.

Host Dave Asprey is the father of biohacking, founder of Danger Coffee and Smarter Not Harder, and a New York Times bestselling author who has spent decades studying human performance, functional medicine, and the science of not aging. As co-founder of Unlimited.Life, a concierge longevity practice that runs over $50,000 in lab work per client, he pulls back the curtain on what the data actually shows once you strip away the marketing.

This is essential listening for anyone serious about biohacking, longevity, anti-aging, human performance, brain optimization, and hacking their own biology with real supplements and functional medicine tools instead of guesswork.

You'll Learn:
Why metformin can cancel out the muscle gains from resistance training and drain your B12 for years
What the 2025 PEARL trial actually found when rapamycin was tested in healthy adults
Why statins carry a 100-to-1 harm-to-benefit ratio and quietly starve your mitochondria of CoQ10
How tadalafil supports nitric oxide, vascular health, and neuroplasticity at low daily doses
Why SGLT2 inhibitors trigger ketosis-like metabolic effects and protect kidney function
How acarbose changes gut bacteria and shows some of the strongest longevity data in mouse studies
How low dose naltrexone modulates the immune system and reduces neuroinflammation
How to talk to your doctor about using these drugs off-label for longevity instead of disease treatment

Thank you to our sponsors!
- ALP | Go to alppouch.com, code DAVE for 10% off.
- Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save.
- Kinetic | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.
- Visit www.myvitalc.com/davesfav to unlock Dave’s discount

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Metformin, Rapamycin, Statins, Tadalafil, Cialis, SGLT2 inhibitors, Jardiance, Acarbose, low dose naltrexone, longevity drugs, anti-aging medication, repurposed pharmaceuticals, off-label drugs, mTOR inhibitor, AMPK, autophagy, endothelial dysfunction, CoQ10, insulin resistance, mitochondrial efficiency, senescent cells, nitric oxide, neuroinflammation, vascular health, PEARL trial, Unlimited.Life

Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
01:01 – Intro
03:48 – Metformin
09:18 – Rapamycin
12:55 – Statins
17:28 – Statins & CoQ10
19:38 – Tadalafil
23:43 – SGLT2 Inhibitors
26:12 – Acarbose
28:40 – Low-Dose Naltrexone (LDN)
31:44 – Dosing & Recap
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark glasses: https://truedark.com
Try Danger Coffee: https://dangercoffee.com/discount/davetube
Try Suppgrade Labs: https://shopsuppgradelabs.com/
Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey

The most powerful energy compounds aren't in your local supplement store. They're sitting in Eastern European science, and Thai herbal medicine, completely ignored by an industry that only profits from what it can patent. In this video I break down 7 compounds that have transformed my energy, sharpened my focus, and kept my brain performing like it did decades ago.

You'll also learn:
Why sulbutiamine gets your dopamine receptors to work harder without the crash of regular stimulants
The overlooked amino acid that keeps glutamate and glycine in balance, and why that balance decides how sharp your thinking feels
Why a compound most people have never heard of protects your liver's biological age, and how that quietly determines your brain energy
The orally active peptide reshaping how your body produces its own hormones, and why it could replace the need for TRT in your late twenties or thirties

Thank you to our sponsors!
Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighs or top sirloins in every box for a year with free shipping always.
Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

00:00 – Intro
01:41 – Sulbutiamine
03:00 – Sarcosine
04:14 – Uridine
05:08 – Thunbergia Laurifolia (Trumpet Vine)
05:55 – The Muscle-Energy Connection
06:38 – Dilucene
08:08 – TUDCA
09:06 – ACE 167

Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/
TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Starting your weekend off right, with the king of mindset. We had to replay this one because it's too goo not to!
Meet a man who makes miracles happen. Today, I’m joined in the studio by Hal Elrod, author of the international bestseller The Miracle Morning and his newest book, The Miracle Equation. After overcoming multiple near-death experiences and financial hardships, Hal channeled his adversity into helping others overcome their own challenges. His Miracle Morning approach has impacted millions of lives.

On today’s episode, Hal tells us all about his updated version of The Miracle Morning. He explains SAVERS, the six foundational practices that will transform your morning and change your life. We also talk about tips for hacking your sleep, productivity, and relationships.

Hal shares the stories of his devastating car accident and rare cancer diagnosis—and the superpowers he gained from coming back to life. We explore how these near-death experiences changed his perspective on life and what he values most. He also tackles some tough questions… Should we try to help everyone? What does it mean to be a “man”? And what does it take to truly serve others? There’s so much to take away from Hal’s refreshing and optimistic perspective.

(00:03:20) Creative Ways To Hold Yourself Accountable
(00:13:57) Ditching Veganism
(00:21:08) Hal’s Near-Death Experiences
(00:27:35) Taking Your Health in Your Hands
(00:29:37) Did Hal Come Back With Superpowers?
(00:31:55) Are You Supposed To Help Everyone?
(00:40:51) How the Miracle Morning Changed Hal’s LIfe
(00:43:42) What Does It Mean To Be a “Man”?
(00:51:25) Customizing Your Morning To Meet Your Needs
(00:54:05) The Six Savers for Success
(00:56:53) Tips To Save Your Sleep
(01:01:51) The MVP of Personal Development Practices
(01:06:14) Nourishing Our Connections

Sponsors
-Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide.
-The One Device | Use code DAVE for $10 off at theonedevice.com/dave
-iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

Resources
Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books
Read: The Miracle Morning and The Miracle Equation
Website: halelrod.com
Facebook: Hal Elrod
X: @HalElrod
YouTube: @HalElrod
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.