Biohacking Beauty: The Anti-Aging Skincare Podcast

Most people treat hair, scalp, and skin as three separate problems, each with its own shelf of products. But all three are built from keratin and run on the same growth signals, so thinning hair can say as much about how you're aging as a new wrinkle.
We dive deeper into this in the Biohacking Beauty Podcast with Dr. Amy Spizuoco. We also chat about what's really behind Ozempic hair loss, which hair loss treatments hold up in the evidence, and the popular hair supplement she calls the biggest waste of money.
Dr. Amy Spizuoco, DO, FAOCD, FAAD, is a board-certified dermatologist and dermatopathologist and the founder of True Dermatology in New York City. She is a Clinical Instructor of Dermatology at the Icahn School of Medicine at Mount Sinai, past president of the American Osteopathic College of Dermatology, and serves on the editorial boards of Practical Dermatology and Dermatology Times. She is also co-founder and co-chair of the DermVIP Summit, a dermatology conference dedicated to hair loss and scalp conditions.
What’s Discussed:
(01:25) Why hair, scalp, and skin are more connected than three product shelves suggest.
(04:14) How collagen 17 links thinning hair and thinning skin.
(07:17) Why the future of collagen is protecting what you have, not just rebuilding it.
(10:09) What gray hair and cell senescence reveal about aging in the rest of the body.
(15:26) When to start scalp care, and the scalp symptoms that need attention right away.
(20:33) How the hair growth cycle shortens as you age.
(29:31) What's really behind Ozempic hair loss, and what to put in place before starting a GLP-1.
(37:17) PRP, red light caps, and exosomes: which hair loss treatments actually hold up.
(45:46) The truth behind retinoid "thinning" and finasteride side effects.
(49:54) The hairline changes that mean you should see a dermatologist now.
(53:16) The hair supplement Dr. Amy calls the biggest waste of money.
Listen to this episode of Biohacking Beauty before you spend another dollar on biotin, scalp serums, or rosemary oil.
Resources Mentioned:
Xtressé Nutrient Hair Growth Gummies: shop.advancedderm.com

Related Episodes:
Dr. Alan Bauman: Why Biohackers Are Losing Their Hair Faster Than Everyone Else
Q&A: Your Questions Answered on Exosome Skincare (Everything You Need to Know Before You Try)

Find more from Young Goose:
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at younggoose.com
Instagram: @young_goose_skincare

Find more from Dr. Amy Spizuoco & True Dematology:
Website: true-dermatology.com
Instagram: @drspizderm

In your 40s, skin can suddenly turn red, itchy, flaky, or reactive, sometimes in random places, and most women assume it is just aging or blame their skincare. But the estrogen and progesterone shifts of perimenopause can change how mast cells release histamine at the skin barrier, which means the trigger may be happening inside the body, not inside the bottle.
We dive deeper into this in the Biohacking Beauty Podcast with Dr. Carrie Jones. We also chat about why a retinoid you have used for years can suddenly irritate your skin, why wine hits so differently in your 40s, and the overlooked lab that could explain hair loss and fatigue.
Dr. Carrie Jones, ND, FABNE, MPH, MSCP, is a naturopathic physician who completed a two-year residency in women's health and endocrinology, is board certified through the American Board of Naturopathic Endocrinology, and is a Menopause Society Certified Practitioner. She was the first medical director for Precision Analytical (the DUTCH Test) and the first head of medical education at Rupa Health. She has more than 20 years of experience in women's health and hormones and hosts the Hello Hormones podcast.
What’s Discussed:
(00:21) Why skin can suddenly turn red, itchy, and reactive in your 40s.
(02:20) Why a retinoid you have used for years can start irritating your skin in perimenopause.
(06:00) How mast cells and histamine create redness, welts, and itching that seem random.
(09:43) How bone broth and fermented foods can add to an already full histamine bucket.
(12:01) Why wine affects your liver, hormones, and skin differently in perimenopause.
(16:59) Alcohol-free ways to wind down at night, from holy basil tea to magnesium.
(20:50) What it means if an antihistamine before bed helps you wake up feeling better.
(23:28) Why progesterone is often the first hormone to drop and how that affects mast cells.
(27:46) The overlooked histamine trigger that can worsen PMS and skin, plus the biggest lever of all.
(35:01) Why ferritin belongs on your blood work, how low is too low, and when supplements are not enough.
(43:27) What to ask your doctor for, so you leave with more than another cortisone cream.
(48:27) Rapid fire: estrogen dominance, seed cycling, red wine, and the one thing every woman over 40 should stop doing.
Listen to this episode of Biohacking Beauty before you blame your next flare on aging or your skincare routine.
Resources Mentioned:
Mira Hormone Monitor: miracare.com
Find more from Young Goose:
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at younggoose.com
Instagram: @young_goose_skincare
Find more from Dr. Carrie Jones:
Website: drcarriejones.com
Instagram: @dr.carriejones
YouTube: Dr. Carrie Jones
Podcast: Hello Hormones with Dr. Carrie Jones

Most skincare routines are built by accumulation: a serum that went viral, a cream a friend swore by, whatever promised firmer skin that month. But what drives skin aging at 25 is not what drives it at 45, so a routine that never changes its priorities can spend years working on the wrong problem.
And your birthday is only part of the picture. Some people's skin is running a decade ahead of their age, perimenopause can change what skin needs years before the 40s arrive, and the routine you will actually stick with is usually shorter than the one you think you need. So before you add another product, it is worth knowing what changes in your skin from one decade to the next and what each stage should prioritize.
In this Biohacking Beauty Class, we walk through a skincare protocol for every decade, from protection in your 20s to correction in your 30s and recovery in your 40s, 50s, and beyond. We get into the research tying sun exposure to 80% of visible facial aging, why NAD+ declines in aging skin, what makes many exosome formulas questionable, how to tell if your skin is aging ahead of your age, and the red light specs that actually matter.
What’s Discussed:
(02:17) Why your skin's age matters more than the number on your birthday.
(03:09) The "attention budget" and why a shorter routine often gets better results.
(04:44) The research linking sun exposure to 80% of visible facial aging.
(06:20) What happened when adults used sunscreen every day for four and a half years.
(12:06) Why NAD+ declines in aging skin and what changes after 30.
(15:03) How spermidine and autophagy help skin clear out what has expired.
(22:08) Why exosomes cannot survive alongside vitamin C, acids, and peptides in the same formula.
(24:04) The part of aging in your 40s that sunscreen cannot fully cover.
(26:10) Why perimenopause and menopause mean moving up a stage, whatever your age.
(31:22) A first look at the Youth Activating Ampoule and why some actives have to stay freeze-dried.
(42:05) What to use at home in the weeks around microneedling and laser treatments.
(45:25) What the research says about red light therapy and the specs worth paying for.
(51:53) How to find out if your skin is aging ahead of your age.
Listen to this episode of Biohacking Beauty before you add another product to your routine, so you know what your skin needs at the stage it is actually in.
Resources Mentioned:
Skincare by Age protocol: https://www.younggoose.com/pages/science
Decade-by-Decade Skincare Field Guide
Young Goose AI Facial Scanner
SkinOS™ Longevity Test
Find a Young Goose Professional
Previous Episodes Mentioned:
Anastasia and Amitay with Dave Asprey on The Human Upgrade
Find more from Young Goose:
Website: Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
Instagram: @young_goose_skincare

There is an interesting contradiction in the way we talk about aging. We celebrate using technology to improve sleep, metabolism, cognition, recovery, and longevity, but when the same mindset is applied to appearance, the conversation can suddenly become much more judgmental.
In this episode of Biohacking Beauty, we sit down with Dave Asprey to explore that tension. We get into why he chose a facelift after major weight loss, whether cosmetic procedures belong in the biohacking conversation, and why wanting to look younger is often treated differently from wanting the rest of your body to function younger.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, CEO of Upgrade Labs, host of The Human Upgrade, and co-founder of Unlimited Life. We also talk about how he prepares his body before procedures, what he thinks people misunderstand about peptides, and his takes on GLP face, collagen supplements, Botox, stem cells, and the other tools people are using to change how they age.
What’s Discussed:
[13:02] Why Dave ultimately chose a facelift after major weight loss.
[15:24] Where non-surgical skin treatments reached their limit for the amount of excess skin he wanted to address.
[18:58] Why copying someone else’s longevity or supplement stack can backfire.
[28:59] Where to start when your biological-age markers look good but you still do not like what you see in the mirror.
[30:07] Why sleep, recovery, HRV, and other foundational markers still matter when thinking about aging.
[37:52] The stigma around cosmetic procedures in biohacking and why Dave questions where that line is drawn.
[44:56] Why he believes fear around aging and medical procedures can affect the body’s stress response.
[54:25] GLP-1s, muscle loss, and the changes people notice in facial appearance after weight loss.
Listen to this episode of Biohacking Beauty for a conversation about where “aging naturally” ends, where biohacking begins, and why that line becomes much more complicated when appearance enters the picture.

Find more from Young Goose:
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off atyounggoose.com
Instagram: @young_goose_skincare

Find more from Dave Asprey:
Website:daveasprey.com
LinkedIn: Asprey
Instagram:@dave.asprey
Facebook: Daveaspreyofficial
YouTube: DaveAspreyBPR
TikTok: @daveaspreyofficial
Book: “Heavily Meditated”: https://daveasprey.com/heavily-meditated/

Peptides are everywhere in skincare right now. They are in serums, moisturizers, lip products, cleansers, body washes, and even shampoos, all promising some version of smoother skin, more collagen, or fewer visible signs of aging.
But seeing “peptides” on a label tells you very little about whether the product can actually deliver those results. Which peptide is being used? Is there research behind that specific ingredient? Is there enough of it in the formula? Can it get through the skin barrier? And what happens when it is combined with everything else inside the bottle? So before you buy another peptide serum because the ingredient sounds impressive, it is worth knowing what actually makes a peptide useful for your skin and how formulation, delivery, concentration, and the rest of your routine can affect whether it works at all.
In this Biohacking Beauty Class, we are separating the science from the marketing around topical peptides. We get into which ones have more evidence behind them, what “Botox in a bottle” gets wrong, why some peptide products make more sense than others, and what to look for if your goal is supporting collagen, softening fine lines, and keeping your skin functioning well as it ages.
What’s Discussed:
(01:47) Do peptides actually belong in everything from serums to body wash?
(05:17) The biggest red flag when a skincare product uses peptides as the main selling point.
(08:26) What should actually back up an anti-aging peptide claim.
(11:11) Which topical peptides have more evidence behind them.
(13:01) Why neuropeptides are not really “Botox in a bottle.”
(15:54) What to know about using peptide products with vitamin C, retinoids, and other actives.
(17:46) Why pH, concentration, and the other ingredients in a formula can affect peptide stability.
(21:14) What actually makes a topical peptide product more likely to work.
(22:45) Why healthy skin function still matters when you are trying to support collagen and repair.
(25:09) If you could only add one peptide product to your routine, which type should it be?
Listen to this episode of Biohacking Beauty before another peptide claim on a skincare label convinces you to spend more without knowing what is actually inside the formula.
Previous Episodes Mentioned:
Nathalie Niddam: Peptides, Bioregulators, and the Truth About Skin Longevity
https://podcasts.apple.com/us/podcast/nathalie-niddam-peptides-bioregulators-and-the/id1552026927?i=1000736397042
Nathalie Niddam: The Potential of Peptides in Skin Health and Anti-Aging
https://podcasts.apple.com/au/podcast/nathalie-niddam-the-potential-of-peptides-in-skin/id1552026927?i=1000642759851
Peptides episodes to watch:
Peptides, Bioregulators & The Truth About Skin Longevity | Nathalie Niddam:
: https://www.youtube.com/watch?v=2AoqcXJ_MMc
Why Peptides Are Not the Shortcut Biohackers Think They Are with Chris Duffin: https://www.youtube.com/watch?v=UNPhDZXY6kw
Peptides, Hormones, and the Anti-Aging Protocol Most Women Start Too Late: https://www.youtube.com/watch?v=b_CTcFjeyqQ&t=428s
GHK-Cu Explained: The Copper Peptide That Signals Collagen Repair: https://www.youtube.com/watch?v=qGDNyVtZjl4
Find more from Young Goose:
Website: Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
Instagram: @young_goose_skincare