Eye On A.I.

Nobody has ever built a cell from scratch - assembled entirely from purified molecules on a shelf - that can feed itself, grow, and split into daughter cells through its own genetic activity. Until now. Dr. Kate Adamala, a synthetic biologist and a professor of genetics at the University of Minnesota, whose lab just published a landmark paper on what she calls "spud cells," joins Craig Smith to explain what her team built, why it matters, and what it will take to go from proof of concept to a platform that could eventually replace every molecule civilization currently extracts from petrochemicals. The conversation is as philosophically rich as it is technically specific: Adamala argues that life has no magic ingredient, and that the universe itself is predisposed to give rise to it. She describes the spud cell not as a mic drop but as biology's Sputnik moment: proof that you can escape the gravity well of evolution and build lifelike systems from the ground up.
The episode also covers the most alarming biosecurity question in synthetic biology right now: mirror life - cells built from mirror-image molecules that would be invisible to every immune system on earth and potentially capable of replicating uncontrollably in the environment. Adamala led the global call to pause all mirror life research in 2024, and she explains both why that research was so dangerous and why the spud cell doesn't move the field any closer to that red line. Craig also asks the question nobody else thought to ask: could AI now simulate the billions of years of molecular evolution that a primordial sea would need millions of years to complete - running a few trillion iterations computationally to find what emerges? Subscribe to Eye on A.I. for weekly conversations with the people building and deploying the future of AI.

Nobody has ever built a cell from scratch - assembled entirely from purified molecules on a shelf - that can feed itself, grow, and split into daughter cells through its own genetic activity. Until now. Dr. Kate Adamala, a synthetic biologist and a professor of genetics at the University of Minnesota, whose lab just published a landmark paper on what she calls "spud cells," joins Craig Smith to explain what her team built, why it matters, and what it will take to go from proof of concept to a platform that could eventually replace every molecule civilization currently extracts from petrochemicals. The conversation is as philosophically rich as it is technically specific: Adamala argues that life has no magic ingredient, and that the universe itself is predisposed to give rise to it. She describes the spud cell not as a mic drop but as biology's Sputnik moment: proof that you can escape the gravity well of evolution and build lifelike systems from the ground up.
The episode also covers the most alarming biosecurity question in synthetic biology right now: mirror life - cells built from mirror-image molecules that would be invisible to every immune system on earth and potentially capable of replicating uncontrollably in the environment. Adamala led the global call to pause all mirror life research in 2024, and she explains both why that research was so dangerous and why the spud cell doesn't move the field any closer to that red line. Craig also asks the question nobody else thought to ask: could AI now simulate the billions of years of molecular evolution that a primordial sea would need millions of years to complete - running a few trillion iterations computationally to find what emerges? Subscribe to Eye on A.I. for weekly conversations with the people building and deploying the future of AI.

Companies are spending billions building AI factories, but most of them can't tell you why their AI workloads are failing, whether their GPUs are actually being used, or what their infrastructure is going to cost them when agents start running at scale. Paul Appleby, CEO of Virtana, joins Craig Smith to discuss the findings of their AI Factory Reality Check study, a research report that reveals a striking and underappreciated gap between the pace of AI infrastructure investment and the governance needed to run it safely and efficiently. Six in ten enterprises, the study found, cannot automatically identify root cause when an AI workload fails, a problem that compounds fast once you're running critical services on AI infrastructure at scale.
The conversation covers the mechanics of Virtana's observability platform, capturing 20,000 metrics per second across the entire AI stack, correlating them in real time, and increasingly using agentic capabilities to remediate failures automatically, but its most important insights are structural. Appleby makes a sharp observation that cuts through a lot of AI optimism: token costs are falling, but token consumption is exploding, meaning the total cost of running agentic AI systems is still going up even as the per-unit price drops. He also tracks a cultural shift inside enterprises - IT resilience reporting that used to happen annually now happens weekly - as evidence that technology risk has become a board-level conversation in a way it simply wasn't before. The result is a conversation that's less about the promise of AI and more about what it actually takes to make it work at production scale.
Subscribe to Eye on A.I. for weekly conversations with the people building and deploying the future of AI.

AI is moving faster than enterprise security systems were designed to handle. In this episode of Eye on A.I., Craig Smith speaks with Bradon Rogers, Chief Customer Officer at Island, Island about how companies are struggling to govern the rise of AI agents, browser-based workflows, and unsanctioned AI tools inside the workplace.
The conversation explores why traditional "block-and-control" security models are breaking down and how a new approach, embedding policy directly into the browser and user workflows, may offer a path forward. It also dives into emerging risks like prompt injection and autonomous agent behavior, and why enterprises are increasingly becoming multi-AI environments by default.
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Most AI is built for people sitting at desks. Kriti Sharma builds it for the people who work in refineries, aircraft hangars, and utility networks responding to wildfires at 4 a.m. and she spends weekends on-site with them to make sure what she builds actually holds up. In this episode, Kriti joins Craig Smith to discuss what industrial AI really looks like when failure genuinely isn't an option, and why the gap between an impressive AI pilot and a production-grade AI system is so much wider in the physical world than most technology companies appreciate.
The conversation is grounded in three specific products from Nexus Black, the elite AI unit Kriti leads inside IFS. The first is Resolve, a predictive maintenance platform built in close collaboration with William Grant's - the distillery behind Glenfiddich and Hendricks Gin - that is projected to save £8.4 million per year at a single factory by reading complex engineering schematics, identifying failure patterns before they occur, and giving frontline technicians step-by-step guidance on their phones without requiring them to remove a safety glove to type. The second is an airworthiness compliance tool for commercial airlines that automates a process currently consuming weeks of human engineering time, where a single mistake carries regulatory fines of up to $20 million and grounding a fleet costs $140 million per day. The third is a disaster response coordination system for utilities, built in partnership with Anthropic, designed to help field crews coordinate during wildfires, hurricanes, and grid outages in ways that, as a California disaster responder told Kriti directly after the most recent wildfire season, will get communities back online and hospitals lit up faster than ever before.
Subscribe to Eye on A.I. for weekly conversations with the people building and deploying the future of AI.