Beginner's Mind

• EP 157 - Fabrizio Conicella: Why Europe Keeps Losing the Next Breakthroughs in Medicine

  Europe has the science. The talent. The breakthroughs.But when an idea feels too uncertain, our systems shut it down before it has a chance to breathe.And with every safe bet… we quietly lose the next cure, the next Car-T, the next AI that could change everything. 🚨 Risk-aversion, fragmentation, and bureaucracy are draining Europe’s innovation power—and nobody dares to name it out loud.But Fabrizio Conicella, VP of Open Innovation at Chiesi Group, isn’t holding back. 💡 In this deep, urgent conversation, Fabrizio shares how Europe can build the ecosystems we need to turn bold ideas into real-world impact—without compromising ethics, patients, or long-term value. 🎧 Watch now to explore: 1️⃣ Why uncertainty, not risk, is the true frontier of innovation 2️⃣ The hidden reasons startups leave Europe—and how to keep them 3️⃣ How Chiesi’s “The Impulse” model flips corporate R&D on its head 4️⃣ What every policymaker, CEO, and scientist must change before it’s too late 5️⃣ A bold new playbook for turning visionary science into trusted medicine 👤 About Fabrizio Conicella: As one of Europe’s leading voices in health innovation, Fabrizio is pioneering how pharma collaborates across startups, data, and ethics. His mission: create environments where the best ideas don’t get shut down—they get built. 💬 Quotes That Might Just Change Your Thinking: (01:58:01) "Be bold enough to dream, but pragmatic enough to make it real." (01:07:22) "Science is essential, but turning it into a product requires a different kind of wisdom." (01:04:35) "Visionary entrepreneurs see the future and change the game." (00:16:51) "Innovation today is no longer a race for ownership, but a journey of collaboration." (00:47:55) "If the idea is truly bold, no pharma company can replicate it without you." ⏱️ Timestamps: (03:00) Europe’s Innovation Crisis: A Wake-Up Call (08:19) Chiesi’s Bold B Corp Strategy (16:26) Building Healthcare Innovation Ecosystems (22:09) Predictive Medicine and Patient Data (29:49) Pharma vs. Startup Ecosystems Today (34:38) Why R&D Must Go External (35:06) The End of Buy-and-Wait Pharma (41:42) Ethics First: Pharma’s New Mandate (44:06) Respecting Founders, Not Just IP (47:23) Debunking the 'Pharma Steals Ideas' Myth (54:10) Why Pharma Moves Slowly—but Must Adapt (59:25) Market Acumen: Startups’ Missing Ingredient (01:04:35) What Makes a Visionary Entrepreneur (01:29:22) Embracing Failure to Spark Innovation (01:46:01) Europe’s Risk Culture is Holding Us Back 🔔 Help Us Grow the Future of Thoughtful Innovation If this conversation sparked something in you—an insight, a question, a sense of urgency—help us keep it alive. Subscribe. Leave a comment. Share it with someone who still believes bold ideas deserve a fighting chance. Every action brings in deeper minds, bigger questions, and the kind of leadership our systems so desperately need. Book mention: The Venture Mindset🎧 Watch now—and join the movement to rebuild Europe’s innovation edge. Send us a textSupport the showJoin the Podcast Newsletter: Link

  --------  

  2:00:46
• EP 156 - Janos Pasztor: The Most Controversial Fix for Climate Change

  What if the only way to save the planet... is to cool it? Not figuratively—literally. Because the heatwaves, floods, and fires you’ve seen so far? They’re just the beginning.🌍 Emissions keep rising. Global cooperation is slowing. And the window to act is closing fast. Now, world leaders are quietly weighing a radical idea: Should we artificially cool Earth before it’s too late?💥 In this explosive episode, we dive into the most controversial climate strategy on the table today: solar radiation modification.But who decides how much cooling is “enough”? What happens if we act too late—or worse, too soon?📌 In this episode, Janos Pasztor—former UN Assistant Secretary-General for Climate Change and climate advisor to Ban Ki-moon—breaks his silence on the plans world leaders are only now beginning to confront.🎧 Watch now to uncover: 1️⃣ Why geoengineering may soon become a global necessity—not a fringe idea.2️⃣ What governments aren’t telling you about unilateral climate interventions. 3️⃣ The ethical, political, and scientific minefield behind planetary cooling. 4️⃣ Why some scientists say this tech could save millions—and others call it madness. 5️⃣ What it will take to govern Earth’s thermostat before someone does it alone.👤 About Janos Pasztor: With nearly 50 years of experience in climate policy, diplomacy, and governance, Pasztor has shaped global climate strategy from inside the UN and beyond. From the 1992 Earth Summit to the corridors of the UN Security Council, he’s been advising heads of state on how to confront the world’s most complex crisis—and now, he’s sharing what’s coming next.💡 Quotes to Challenge Your Thinking: (00:08:41) “We must ask: is it time to start cooling parts of the planet?”(01:21:07) “Stratospheric aerosol injection could cool the planet—yet we barely understand its consequences.”(01:11:03) “The real question is whether capitalism can evolve beyond its dependence on resource extraction.”(02:24:41) “Three degrees of warming is cuckoo land—it’s beyond what humanity can realistically adapt to.”(02:47:03) “Climate policy isn't just climate—it’s about everything we do as a society.”⏱️ Timestamps: (00:04:12) Urgent Climate Crisis: Rising Emissions Explained (00:10:15) Inconvenient Truth 2.0: What We Missed (00:18:32) China’s Green Tech Revolution Unpacked (00:26:20) Can Climate Forums Deliver Real Action? (00:32:50) Designing Just, Achievable Climate Goals Globally (00:40:06) How Growth Triggers Today’s Polycrisis (00:45:08) Rethinking Economies for Sustainable Living (00:53:00) Why We Need Mixed Energy Strategies (01:17:24) Geoengineering vs Terraforming: Climate Futures Debate (01:26:20) Who Funds Carbon Removal Technologies? (01:37:06) Why We May Need to Cool Earth (01:40:41) Warming Beyond 3°C: What’s at Risk (01:48:02) How Fossil Fuels Hide True Heat (02:08:00) The Hidden Risks of Cheap Climate Fixes (02:24:41) 3 Degrees Warming: Scientifically Unmanageable? 🔔 Help Us Grow If this conversation gave you insight, urgency, or a new perspective—help us keep it going. Subscribe. Leave a comment. Share it with someone who cares. Every single action helps us invite world-class thinkers, spark deeper debates, and bring you the conversations that actually matter.🎧 Watch now—and be part of the climate conversation no one dares to start.Send us a textSupport the showJoin the Podcast Newsletter: Link

  --------  

  2:59:21
• #155: Ray Dalio’s Playbook — 7 Principles for Building Scalable, Resilient Companies

  What if your business ran like a well-designed machine—one that could evolve, self-correct, and outperform your competition over decades?In this episode, I unpack Principles by Ray Dalio, the billionaire investor and founder of Bridgewater Associates, the world’s largest hedge fund. It’s not a traditional business book—it’s a blueprint for decision-making, culture design, and long-term scaling, rooted in clarity, transparency, and radical self-honesty.This episode is built for venture capitalists, executives, and operators leading at scale—those who are no longer improvising but building enduring systems.You’ll hear the 7 most actionable principles Dalio used to scale Bridgewater, reimagined for anyone building the future—from biotech to AI, from global funds to market-leading enterprises.We cover how to engineer feedback cultures, design for evolution, and drive decisions that compound over time. And we tackle the big question: Can you be both a high-performance machine and a human-centered leader?Key Takeaways:Think Like a Machine: Build systems that run without your constant input.Get the People Right: Talent isn’t enough—character and growth capacity matter most.Radical Transparency: Trust is built by saying the hard things early and often.Idea Meritocracy: Don’t default to consensus. Weight decisions by experience.Shaper Thinking: Zoom out to vision, zoom in to execution—and toggle constantly.Diagnose the Root Cause: Don’t waste time solving symptoms.Open-Mindedness as Strategy: Challenge your thinking before reality does.Timestamps:(00:00) Intro: The Principles(02:15) Why This Book Matters If You’re Building or Investing in the Future(04:14) Who Is Ray Dalio?(06:21) The Snapshot: What Principles Is Really About (10:05) Build Your Company Like a Machine, Not a Hero’s Journey (15:29) Get the People Right (20:40) Radical Truth & Transparency Are Force Multipliers (26:08) Build an Idea Meritocracy (32:26) Shapers Win—They Dream Big, Think Clear, Execute Ruthlessly (37:37) Diagnose Root Causes, Not Symptoms (44:02) Be Radically Open-Minded (50:12) Key Takeaways & Personal ReflectionWhy Listen:Learn how billion-dollar systems are designed and scaledIdentify blind spots in your leadership, org design, or investment thesesEquip yourself with 7 operating principles you can implement this quarterReframe your relationship to truth, conflict, and growthDecide whether to build a machine—or remain the operatorIf these ideas resonate, I strongly recommend reading Principles in full. Or better yet—share this episode with someone you think is ready to level up how they lead and build.Send us a textSupport the showJoin the Podcast Newsletter: Link

  --------  

  56:56
• Suzanne Heywood | From Shipwreck to Boardroom Leadership (SPARK20 - 133)

  What does it take to turn extreme adversity into extraordinary leadership? Suzanne Heywood’s life reads like a novel—shipwrecked at seven, isolated at sea for a decade, forging her father’s signature to survive, and ultimately earning a place at Oxford through sheer determination. Today, she’s a top executive and investor, steering multi-billion-dollar companies with resilience, clarity, and innovation.In this episode, Suzanne shares the defining moments that shaped her, the mindset that helped her thrive in crisis, and the leadership lessons she applies in business today. Whether you’re an investor, entrepreneur, or leader, this conversation will leave you inspired and armed with valuable insights:How to stay calm under extreme pressure and make clear decisions.Why resilience isn’t about being tough—but about perspective.How diversity fuels innovation and why biases hold companies back.The ‘Critical Friend’ approach to leadership and board dynamics.At the heart of it all, Suzanne’s journey is a testament to perseverance and purpose. As she says:"You’ll learn things from adversity that people with an easier life never will."Timestamps & Topics📌 (01:00) Overcoming Extreme Adversity – A childhood lost at sea, a future built from nothing. 📌 (03:43) Knowing Which Mountains Are Worth Climbing – How to distinguish real challenges from distractions. 📌 (06:05) Resilience Under Pressure – From shipwreck to boardroom calm. 📌 (07:51) The Dangers of Bias in Innovation – Why lack of diversity kills progress. 📌 (09:39) Creating Sustainable Innovation – What great leaders prioritize for long-term success. 📌 (13:48) The ‘Critical Friend’ in Leadership – Balancing support with hard truths. 📌 (16:43) Metallica Meets Electric Trucks – A masterclass in creative partnerships. 📌 (18:29) Education as the Ultimate Investment – How learning transformed her life.Powerful Quotes💡 (03:43) "I picked kiwifruit… earned enough for a one-way ticket—Oxford changed my life." 💡 (06:58) "Nobody's life is in danger—we will get this sorted out." 💡 (20:39) "You’ll learn things from adversity that people with an easier life never will."This episode is more than an inspiring story—it’s a blueprint for navigating uncertainty, making tough decisions, and leading with conviction.👉 Listen now, take notes, and if this sparks something in you, share it with someone who needs to hear it!Send us a textSupport the showJoin the Podcast Newsletter: Link

  --------  

  21:26
• EP 154 - Kristina Levan: Why Life-Saving Therapies Aren’t Reaching Patients—And How to Fix It

  ATMPs, gene therapies, and cancer breakthroughs are here—but outdated regulations, high costs, and logistical bottlenecks are blocking access. What needs to change for hospitals to deliver these cures to patients who need them most?💡 Here’s the harsh reality:Patients are waiting, but hospitals aren’t ready.The science exists, but regulations haven’t caught up.The treatments work, but they’re too expensive to scale.So what’s the solution? And who’s taking action?📌 In this episode, Kristina Levan—ATMP innovation leader and biotech strategist—breaks down the challenges and opportunities shaping the future of advanced therapies.🎧 Watch now to learn: 1️⃣ How gene therapy is curing blindness—and why it almost didn’t happen. 2️⃣ The biggest bottleneck preventing hospitals from offering life-saving treatments. 3️⃣ How AI and automation could unlock personalized medicine for everyone. 4️⃣ The real reason ATMPs are so expensive—and what must change. 5️⃣ Why healthcare leaders, policymakers, and investors must rethink how we manufacture cures.👤 About Kristina Levan: Kristina Levan has spent years at the cutting edge of cancer research, clinical trials, and ATMP development. She’s helped shape Sweden’s national ATMP strategy, connecting industry, healthcare, and academia to push these breakthroughs forward. Now, she’s tackling the next big challenge—getting these treatments to patients faster.💡 Quotes to Challenge Your Thinking: (00:12:05) "ATMPs don’t just treat symptoms—they have the power to cure diseases." (00:23:36) "Gene therapy is giving children a future—restoring sight and transforming their lives forever." (01:27:52) "Imagine a future where hospitals create customized gene therapies on-site for every patient." (01:43:13) "ATMPs could transform lives by treating the untreatable." (01:45:42) "If we can cure early, we don’t just save lives—we reshape them."Timestamps: (00:05:32) How ATMPs Will Reshape Global Healthcare (00:13:54) CAR-T Therapy: The Next Cancer Treatment Revolution (00:23:36) Gene Therapy Restores Sight—The Future of Medicine? (00:28:33) AI-Powered Therapies: Can Hospitals Manufacture Cures? (00:37:55) Why Cutting-Edge ATMPs Struggle to Reach Patients (00:53:36) Personalized Medicine & Real-Time Health Monitoring (01:09:02) From Research to Reality: Scaling ATMP Treatments (01:12:54) The True Cost of ATMPs—Can We Afford Innovation? (01:27:15) Cell Therapy Manufacturing: The Next Big Disruption (01:33:03) AI & Automation in Healthcare: What’s Next?🔔 Help Us GrowIf this episode gave you insight, inspiration, or a new perspective—here’s how you can help:📢 Hit SUBSCRIBE, like, and leave a comment. It’s a small action, but it has a huge ripple effect. Every engagement helps us bring in bigger guests, deeper insights, and more industry-changing conversations.Right now, we’re in the global top 10%—let’s push for the top 1% together.🎧 Watch now and be part of the conversation shaping the future of medicine. 🚀Send us a textSupport the showJoin the Podcast Newsletter: Link

  --------  

  1:51:29

Weitere Wirtschaft Podcasts

Trending Wirtschaft Podcasts

Über Beginner's Mind