Commune with Jeff Krasno

NAD+ has become the longevity industry's favorite molecule, sold as as a supplement and as a four-hour IV that promises sharper thinking, more energy, and slower aging. But a new 2026 paper complicates the very story it was built on.

In this episode, Jeff breaks down what NAD+ actually is, what the human trials really show, and why the gap between a $40 oral supplement and a $1,200 IV drip matters more than the marketing admits.

You’ll learn about:

What NAD+ does in the body and why it got tied to aging

The new research questioning whether NAD+ truly declines with age

Oral NR and NMN versus IV infusions, and what the evidence supports

The risks rarely mentioned, including the cancer question

Why the saline, B vitamins, and forced rest may explain how good people feel

This episode is for anyone weighing NAD+, longevity supplements, or an IV drip, and who wants to tell real science from wellness hype first.

This episode was made possible by:

LMNT: Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase at drinklmnt.com/commune.

Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD

Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 15% off your order at ⁠vivobarefoot.com/commune⁠.

Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line.

Sunlighten: Visit sunlighten.com/commune Up to 2,100 off saunas and $50 off Red Light Products with code “COMMUNE”

How do you regulate your nervous system in a world built to hijack it?

In this episode, Jeff sits down with Sam Harris, neuroscientist, author, and creator of the Waking Up meditation app, for part two of a two-part conversation. After diagnosing the political chaos in part one, they pivot to the practice of meeting it with clarity, exploring mindfulness, non-duality, and what's prior to thought.

They discuss:

Why almost no one can hold attention for 30 seconds

The real root of psychological suffering

Dualistic vs. non-dualistic meditation practice

Psychedelics and meditation compared

The social construction of the self, from childhood to Sartre

The hard problem of consciousness and the mystery of awareness

If you want to learn Sam’s approach to staying engaged with the world without losing your mind to it, go to https://onecommune.com/sam to get 30 days of his Waking Up app for free.

This episode was made possible by:


Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 15% off your order at ⁠vivobarefoot.com/commune⁠.


Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD


LMNT: Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase at drinklmnt.com/commune.


Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line.


Sunlighten: Visit sunlighten.com/commune Up to 2,100 off saunas and $50 off Red Light Products with code “COMMUNE”

Liver detoxes are a $10 billion industry. The liver is also the most regenerative organ in the body, running its own continuous cleanse without your help.

In this episode of The Commune Podcast, Jeff Krasno walks through what's actually known about liver health, from juice cleanses to gallbladder flushes to the supplements lining every wellness aisle.

How the liver actually metabolizes and clears toxins

Why the green "stones" in popular flushes are just solidified olive oil

Fatty liver disease, fructose, and the irony of fruit-heavy cleanses

The evidence for coffee, cruciferous vegetables, exercise, and fiber

Which supplements have real research: milk thistle, berberine, NAC, sulforaphane

This episode is for anyone considering a cleanse who wants to know what works, what doesn't, and what's worth their money.

This episode was made possible by:

Sunlighten: Visit sunlighten.com/commune Up to 2,100 off saunas and $50 off Red Light Products with code “COMMUNE”

Beyond Biohacking: Save $400 on any ticket with code COMMUNE400 at beyondconference.com.

Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 15% off your order at ⁠vivobarefoot.com/commune⁠.

Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line.

LMNT: Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase at drinklmnt.com/commune.

Sam Harris has two brains. One is making sense of the political chaos. The other is waking up from it.

In this episode, Jeff sits down with Sam Harris, neuroscientist, author, and host of the Making Sense podcast, for part one of a two-part conversation on surviving the modern world with your sanity intact. They unpack the outrage machine, political tribalism, and what it actually takes to stay clear-headed inside the noise.

They discuss:

Why Sam finally quit Twitter after 12 years, and what changed

How the attention economy fuels hyper-partisanship and authoritarianism

The moral panic around race, and how it radicalized the center

Immigration policy, deportation, and the abandonment of Afghan allies

Free speech, Orbán's defeat, and the future of liberal democracy

If you want to learn Sam’s approach to staying engaged with the world without losing your mind to it, go to https://onecommune.com/sam to get 30 days of his Waking Up app for free.

This episode was made possible by:


Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 15% off your order at vivobarefoot.com/commune.


Sunlighten: Visit sunlighten.com/commune Up to 2,100 off saunas and $50 off Red Light Products with code “COMMUNE”


Beyond Biohacking: Save $400 on any ticket with code COMMUNE400 at beyondconference.com.


LMNT: Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase at drinklmnt.com/commune.


Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line.

Creatine is one of the most researched and most misunderstood compounds in the supplement aisle.

In this episode, Jeff walks through what the evidence actually says about creatine for muscle, brain health, aging, and women's health, and where the legitimate cautions sit.

Inside:

How phosphocreatine fuels muscle and brain cells

New 2024 and 2025 research on cognition and women's hormonal health

Sarcopenia, emerging Alzheimer's trials, and aging well

What to buy (creatine monohydrate, Creapure, NSF Certified) and what to skip

Why bipolar history, kidney disease, and chronic NSAID use matter

This episode is for anyone curious about creatine, women navigating perimenopause and menopause, and adults thinking ahead about strength and cognitive longevity.

This episode was made possible by:

Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD

Sunlighten: Visit sunlighten.com/commune Up to 2,100 off saunas and $50 off Red Light Products with code “COMMUNE”

Beyond Biohacking: Save $400 on any ticket with code COMMUNE400 at beyondconference.com.

LMNT: Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase at drinklmnt.com/commune.

Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line.