#72: John Rolston — Closed-Loop Stimulation, Seizure Dynamics, and the New Frontiers of Epilepsy Treatment
Today, we had the privilege of speaking with Dr. John Rolston, a leading voice at the intersection of neurosurgery, epilepsy, and brain stimulation.Dr. Rolston is an Associate Professor of Neurosurgery at Harvard Medical School and the Director of Epilepsy Surgery at Brigham and Women’s Hospital. His pioneering work bridges clinical neurosurgery and computational neuroscience, focusing on how electrical stimulation can modulate dysfunctional brain networks to treat epilepsy, movement disorders, and disorders of consciousness.In this episode, we explored the complexities of neuromodulation—what makes stimulation effective, why patient-specific targeting matters, and how brain states influence therapeutic outcomes. Dr. Rolston also shared his lab’s work on traveling waves in the brain and how these insights are transforming seizure localization and surgical decision-making. From closed-loop stimulation to stem cell therapy for Parkinson’s disease, Dr. Rolston walks us through the evolving landscape of functional neurosurgery and its future.
Andreas Horn interviews experts in the field of deep brain stimulation, noninvasive neuromodulation, functional brain imaging and neuroanatomy. Join us on our quest to interact with the human brain and thank you for your interest in science!
Andreas Horn, M.D., Ph.D., directs the institute for network stimulation and is a professor for computational neurology at University Cologne.
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