Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, Nutrition

Watch the FULL podcast here: https://youtu.be/QeNdkCVYquUCan nutrition and supplements meaningfully lower dementia risk or mainly boost day-to-day focus? They matter within a broader Three S model that links stimulus, supply, and support for brain adaptation. This clip explores why cognitive challenge is the primary stimulus, how supply depends on blood flow, oxygen, and fuel, and how support includes sleep and less chronic stress. We discuss omega-3s, B vitamins, choline, vitamin D, magnesium, zinc, iron, and hydration, the heart-brain connection, and vascular dementia overlap, plus associations showing compounded risk from low D, poor omega-3 and B status, anemia, and homocysteine. ***This episode is sponsored by: NOWATCH: Health tracking reimaginedKnow your body, trust yourself.15% off with code LWBW15 at nowatch.com***The Great British Veg OutHow to support your gut, energy, and hormones by eating more — not less.👉 sarahannmacklin.com/vegoutReset Your HealthIf your body feels off after stress, travel, or burnout — this is where to start.👉 sarahannmacklin.com/reset-your-health👉 Practical beats perfect.Here’s a free 5-recipe PDF I use to support energy and stress during busy weeks.https://sarahannmacklin.com/5_free_recipes👉 If this resonates, you can join the thousands who readThe Compassionate Cure each week.https://sarahmacklin.substack.com/***Let’s be friends!📷 Instagram: https://www.instagram.com/sarahannmacklin/📹 Subscribe: http://www.youtube.com/@livewellbewellsarah🐦 Twitter: https://x.com/SarahAnnMacklin📱 TikTok: https://www.tiktok.com/@livewellbewellpodcast💌 Newsletter: https://sarahmacklin.substack.com/

Are GLP-1 weight loss drugs a smart first step for obesity? They’re helping many people lose significant weight, yet concerns remain about side effects, muscle loss, cost, and regaining weight after stopping. This clip explores the promise and limits of GLP-1s, the call for long term data, and the need to pair medication with nutrition education, counseling, and strength training. It also considers real world access and whether short term success can translate into lasting health. ***This episode is sponsored by: NOWATCH: Health tracking reimaginedKnow your body, trust yourself.15% off with code LWBW15 at nowatch.com***The Great British Veg OutHow to support your gut, energy, and hormones by eating more — not less.👉 sarahannmacklin.com/vegoutReset Your HealthIf your body feels off after stress, travel, or burnout — this is where to start.👉 sarahannmacklin.com/reset-your-health👉 Practical beats perfect.Here’s a free 5-recipe PDF I use to support energy and stress during busy weeks.https://sarahannmacklin.com/5_free_recipes👉 If this resonates, you can join the thousands who readThe Compassionate Cure each week.https://sarahmacklin.substack.com/***Let’s be friends!📷 Instagram: https://www.instagram.com/sarahannmacklin/📹 Subscribe: http://www.youtube.com/@livewellbewellsarah🐦 Twitter: https://x.com/SarahAnnMacklin📱 TikTok: https://www.tiktok.com/@livewellbewellpodcast💌 Newsletter: https://sarahmacklin.substack.com/

In this episode of Live Well Be Well, I’m joined by Dr. William Li, physician scientist, bestselling author, and president of the Angiogenesis Foundation. William is one of the world’s leading voices on food as medicine, and together we explore how nutrition, immunity, and brain health are deeply connected, often in ways we underestimate.In this conversation, Dr. William Li shares how the body’s defence systems are constantly communicating with the brain, influencing inflammation, cognition, mood, and ageing. Drawing on decades of research, he explains how everyday foods can strengthen immunity, protect blood vessels, and support brain function, not through restriction or perfection, but through consistent, nourishing choices.We discuss why immune health matters far beyond avoiding illness, how inflammation silently impacts mood and cognition, and why nourishing the body is one of the most accessible tools we have for long term resilience. This episode is an invitation to move away from fear based nutrition and toward a calmer, evidence led understanding of how the body heals, adapts, and thrives when supported consistently over time.Here’s What We Dive Into:- How the immune system influences brain health, mood, and cognitive ageing.- Why chronic inflammation quietly undermines wellbeing long before symptoms appear.- What angiogenesis is and why healthy blood vessels matter for brain function.- How specific foods support the body’s natural defence and repair systems.- Why food as medicine is about consistency, not restriction or perfection.- What the science really says about nutrition and disease prevention.- How everyday dietary choices shape long term resilience and longevity.- Why empowering people with knowledge creates healthier relationships with food.Love, Sarah Ann 💛***This episode is sponsored by:NOWATCH: The compassionate health trackerConnecting body and mind with unique stress recovery insights so you can live fully today15% off with code LWBW15 at nowatch.com***👉 Practical beats perfect.Here’s a free 5-recipe PDF I use to support energy and stress during busy weeks.https://sarahannmacklin.com/5_free_recipes👉 If this resonates, you can join the thousands who readThe Compassionate Cure each week.https://sarahmacklin.substack.com/***Let’s be friends!📷 Instagram:  / sarahannmacklin📹 Subscribe:   / @livewellbewellsarah  🐦 Twitter:  / sarahannmacklin  📱 TikTok:  / sarahannnutrition  💌 Newsletter: https://sarahmacklin.substack.com/***Sign up to Sarah’s Compassionate Cure newsletter:Science Simplified, Health Humanised.Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact.https://sarahmacklin.substack.com/***Intro (00:00)Why Social Connection Is Essential for Longevity and Brain Health (02:11)Reframing Ageing and Letting Go of the Decline Narrative (04:26)How Metabolism Shapes Ageing, Energy, and Disease Risk (11:03)Why Biohacking Misses the Bigger Picture of Longevity and Health (15:26)The Brain Microbiome and How Gut Bacteria Affect the Mind (19:12)Probiotics and Brain Health What the Science Shows (23:29)How to Choose the Right Probiotic Based on Evidence (30:40)Akkermansia and Its Role in Metabolism and Diabetes (35:46)Gut Health, Immunity, and Cancer Treatment Support (40:02)How to Increase Akkermansia Naturally Through Diet (41:37)Do Restrictive Diets Support or Harm Gut Microbiome Health? (47:56)Hydration, Polyphenols, and Healthier Beverage Choices (50:54) The Simple Hydration Habit That Prevents Mindless Eating (57:12)Balancing Longevity Goals With Joy and Simplicity (1:01:42)***Love what you’re hearing?My small ask is to please rate and review Live Well Be Well. This helps the show expand and allows me to keep producing these with the best quality guests. It means a huge amount to me, so thank you.

👉 Practical beats perfect.Here’s a free 5-recipe PDF I use to support energy and stress during busy weeks.https://sarahannmacklin.com/5_free_recipes👉 If this resonates, you can join the thousands who readThe Compassionate Cure each week.https://sarahmacklin.substack.com/Watch the FULL podcast here: https://youtu.be/QeNdkCVYquUDoes having APOE4 mean Alzheimer’s is inevitable? It doesn’t, and I explain how genes interact with lifestyle and environment to shape risk. This clip explores early-onset familial mutations versus common late-onset cases, APOE4 as a risk multiplier, population data from some Indigenous groups, Nigerians, and Sicilians, key lifestyle factors like smoking, alcohol, poor diet, and sedentary behavior, polygenic risk scores, and why an estimated 40 to 50 percent of dementia may be preventable at a population level.***This episode is sponsored by: NOWATCH: Health tracking reimaginedKnow your body, trust yourself.15% off with code LWBW15 at nowatch.com***The Great British Veg OutHow to support your gut, energy, and hormones by eating more — not less.👉 sarahannmacklin.com/vegoutReset Your HealthIf your body feels off after stress, travel, or burnout — this is where to start.👉 sarahannmacklin.com/reset-your-health***Let’s be friends!📷 Instagram: / sarahannmacklin📹 Subscribe: / @livewellbewellsarah 🐦 Twitter: / sarahannmacklin 📱 TikTok: / livewellbewellpodcast 💌 Newsletter: https://sarahmacklin.substack.com/

Watch the FULL podcast here: https://youtu.be/ZXLWY5HcPXEIn this conversation, I sit down with Andy Galpin to talk about sleep, and why so many of us are still struggling with it despite doing “all the right things”.We unpack why sleep is getting worse globally, even as awareness and spending on sleep continue to rise. Andy explains why focusing on sleep duration alone misses the bigger picture, and why exhaustion is not the same as being physiologically ready for sleep. We also explore why waking up around 2–3am is so common, and how stress, heart rate, and nervous system regulation before bed play a bigger role than most people realise.***This episode is sponsored by: NOWATCH: Health tracking reimaginedKnow your body, trust yourself.15% off with code LWBW15 at nowatch.com***Sign up to Sarah’s Compassionate Cure newsletter: Science Simplified, Health Humanised. Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. https://sarahmacklin.substack.com/***Let’s be friends!📷 Instagram: / sarahannmacklin📹 Subscribe: / @livewellbewellsarah 🐦 Twitter: / sarahannmacklin 📱 TikTok: / sarahannnutrition 💌 Newsletter: https://sarahmacklin.substack.com/