JAMA Clinical Reviews

Restless legs syndrome is a sleep-related neurologic disorder that causes an overwhelming urge to move the limbs, which can cause substantial sleep disturbance. Author John W. Winkelman, MD, PhD, of Harvard Medical School joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss the symptoms, risk factors, diagnosis, and treatment of restless legs syndrome.

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Restless Legs Syndrome

Mifepristone used with misoprostol is the most common abortion regimen in the US. It is also a focal point of reproductive health policy and politics, with controversy over its legal status and regulation by the US Food and Drug Administration (FDA). Author G. Caleb Alexander, MD, MS, from Johns Hopkins discusses this and more with JAMA Deputy Editor Joseph S. Ross, MD, MHS.

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The US Food and Drug Administration's Regulation of Mifepristone
Politics, Science, and the Future of FDA Drug Regulation

Incidence rates of gastric cancer in younger individuals are on the rise and gastric cancer is the fifth-leading cause of cancer-related deaths worldwide. JAMA Review author Haeseong Park, MD, MPH, from the Dana Farber Cancer Institute, discusses this and more with JAMA Senior Editor Karen Lasser, MD, MPH.

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Gastric Cancer

JAMA Deputy Editor Mary McDermott, MD, and JAMA Deputy Editor Kristin Walter, MD, MS, highlight their selections of top JAMA Clinical Reviews podcasts in 2025.

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Managing Adverse Effects of Obesity Medications
Diagnosis and Management of Hypothyroidism
Type 2 Diabetes: Diagnosis and Current Guidelines for Treatment
Managing Adverse Effects of Incretin-Based Medications for Obesity
Hypothyroidism
Diagnosis and Treatment of Type 2 Diabetes in Adults
JAMA Editors' Choice 2024: Clinical Reviews Podcasts

In this episode, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and Medical News Director Jennifer Abbasi discuss the journal's inaugural Research of the Year roundup.

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Research of the Year 2025